Gene therapy for

Epigenetic gene regulation

ABOUT Episwitch Rx

EpiSwitch Rx is a gene therapy biotechnology company developing therapeutics for neuromuscular conditions.


We are developing epigenetic tools to treat the root cause of disease. 

Our most advanced preclinical program is a CRISPR-based approach to treat the underlying cause of FSHD (facio scapulo humeral muscular dystrophy) which affects over 1 million people worldwide.


Our Mission

Our vision is to bring new treatments and therapies to patients with muscle disorders.

There are over 5.5 million people affected by a muscular dystrophy.  

In many cases these are orphan or rare diseases and there are no available treatment options.   

By bringing together the best scientists, key opinion leaders and disease experts, and working directly with patient communities, clinicians, payors and other health stakeholders, we hope to make a transformational difference and change lives. 

Male Scientist

FSHD (facioscapulohumeral muscular dystrophy)

FSHD is an epigenetic gain-of-function neuromuscular disorder caused by the misexpression of DUX4 protein in skeletal muscle.

CRISPRi therapy for FSHD

CRISPR inhibition restores a more normal state of epigenetic repression at the DUX4 gene, making it an ideal candidate for FSHD therapy.


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